Unfortunately, the currently planned Bulbasaur/Pidgey route runs into this problem in the Saffron City Pokemon Center - the game must be reset before healing or talking to other NPCs. Recorded in Bizhawk 1.6

A new glitch in Pokemon Blue (and presumably Red) that involves using the black-out variant of the Trainer-Fly glitch and then talking to the old man of Missingno. fame. Recorded in Bizhawk 1.5.3. If someone can find the source of the junk data and turn it into something useful, as with MrWint's current glitched run, this could lead to a substantial improvement. The gameplay itself is far from optimized, Squirtle should be able to knock out Charmander with 3 Critical Hits and a wild Pikachu could knock out Charmander with 2 Critical Hits.

An alternative version of my River City Ransom TAS. If no input is made after the input ends, the final boss will defeat himself in 15 seconds. The input file is 10 seconds shorter but the total gameplay is 5 seconds longer.