It's awesome! I'm honored to have been able to encode this great TAS. It's a great improvement over Comicalflop's run and is as entertaining-to-watch a platformer game as ever.
In case anyone missed it in the submission message, a link to the 10-bit 4:4:4 encode is here:
http://lex.clansfx.co.uk/media/video/yoshisstory-tas-bobmario511_10bit444.mkv
I believe this encode is publishable. The previous encode is 1/4 the video resolution (320×240) and this encode is less than double the file size and looks far far better. Also, this one has the proper levels. :P The 8-bit 4:2:0 version is encoding right now. ETA from the time of this edit is ~3h15m.
Edit: An 8-bit 4:2:0 compatibility encode for old systems is available
here. With the same settings as the 10-bit 4:4:4 encode, this video is slightly bigger (~4 MB bigger).