Ninja Five-O features a ninja cop battling evil ninja masters and terrorists.
Joe Osugi, bizarre 'anti-terrorist ninja', is called in to assist the local police, who seem to be completely useless in rescuing some hostages.
The game is basically a series of rooms connected together. Your job is to rescue the hostages and then escape the stage through the red door. You have in your arsenal a three-level shuriken, a sword, and a grappling hook similar to the one from Bionic Commando. Joe also has two special abilities: to make himself invincible and to attack all enemies on screen.