Mega Man Xtreme 2, like its predecessor game Mega Man Xtreme, pretty much copies content and bosses from the main line of Mega Man X games. However, Xtreme 2 gets ideas and designs from a much wider range of games, ranging all the way from Mega Man X to Mega Man X5. For instance, there is a Parts system allowing upgrades to your characters. However, there is also an original story (though it's still as silly as many Mega Man storylines), along with some new stage designs and bosses.

Noxxa and Alyosha improve the previous run by about 2 seconds if emulation differences are not accounted for, thanks to using Zero throughout the entire game instead of splitting between X and Zero.

This run starts from a save file in order to unlock "Extreme Mode", which allows visiting all of the game's stages and battles in one run. Runs that start from SRAM are not normally allowed; see the Movie Rules for more on this.

Viewers who have photosensitivity problems may want to avoid watching as there's a high amount of flashing visuals during boss fights that can become uncomfortable to watch.

You can watch the complete run played back on console.