Figure I may as well get the discussion ball rolling. I've no plans to TAS this game currently, but I can always get some route planning done.
First thing that is good for a TAS is that we can cut down on the number of weights needed to go out of the way for with drop manipulation. Coin drops are small so they'll probably add up to 2-3 less pots needed to pick up over an entire run, and the subweapon drops are probably also as negligible, but may save some time. Since a TAS will be single segment and not reloading from save, the amount of pots for coins and weapons are still rather tight.
Speaking of subweapons, absolute best bosskiller is the Flares, so ideally any subweapon drops will want to go towards that once they are obtained. Current speedrun strategies have quick kills on Ellmac, Amphis, Viy, Shu and Bahamut all using Flares (and often some use of Athletic Land + Cabbage Patch Kids for the extra invincibility from damage). Since the bosses can be done in almost any order and they can be basically taken out at any time, it would be worthwhile collecting a bunch of items before even tackling one of them.
There's quite a few glitches in the game too - out of bounds is possible, but usually requires some damage boost from a bat or something. There's also the Zombie Lemeza glitch, which makes the protagonist basically invincible but has its drawbacks (being unable to enter the menu until you save being a major one).
http://www.youtube.com/v/CzuuNH4MSuQ
http://www.youtube.com/v/NsYQtTTzc4U
Zombie Lemeza glitch in action.
http://www.youtube.com/v/8cSmp7_ERjQ
Viy quick kill
(thanks to Anonymous52555 and TheMaxican for these videos)
Currently there are three realtime runs being worked on - 100% segmented, low% segmented, and any% single segment, all by different people, so there's never a better time to get a TAS started!