| Id | Name | Systems | Actions |
|---|---|---|---|
| 3865 | Saint Sword | Genesis | |
| 3174 | Saiyuki: Journey West | PSX | |
| 1008 | Saiyuuki World | NES | |
| 3241 | Salamander | NES | |
| 639 | Salary Man Champ: Tatakau Salary Man | PSX | |
| 3758 | Saloon Shootout | C64 | |
| 3569 | Sammy Lightfoot | C64 | |
| 4042 | Samorost | Flash | |
| 2594 | Samurai Shodown | Arcade | |
| 2049 | Samurai Shodown II | PSX, Arcade | |
| 1682 | Samurai Shodown IV: Amakusa's Revenge | Arcade | |
| 4086 | Samurai Warrior: The Battles of Usagi Yojimbo | ZXS | |
| 923 | San Francisco Rush 2049 | N64 | |
| 1194 | Sangokushi 2: Haou No Tairiku | NES | |
| 1250 | Sanrio World Smash Ball! | SNES | |
| 3027 | Santa Claus Saves the Earth | GBA | |
| 3660 | SASA | SVI3x8 | |
| 1561 | Saturday Night Slam Masters | SNES | |
| 1555 | Saturn Bomberman | Saturn | |
| 3334 | Sayonara Wild Hearts | Linux, Windows, MacOS | |
| 1428 | Scion | MSX | |
| 3022 | Scooby-Doo 2: Monsters Unleashed | GBA | |
| 4205 | Scooby-Doo and the Cyber Chase | GBA | |
| 1063 | Scooby-Doo! Classic Creep Capers | N64 | |
| 1792 | Scooby-Doo! Classic Creep Capers | GBC |