| Id | Name | Systems | Actions |
|---|---|---|---|
| 1835 | Scooby-Doo! Mystery Mayhem | GBA | |
| 3393 | Scooby-Doo! Unmasked | GBA | |
| 2551 | Scrabble | GBC | |
| 1816 | Scrapyard Dog | Lynx | |
| 1875 | Scrapyard Dog | A7800 | |
| 3016 | Scribblenauts Collection | DS | |
| 1549 | Seaquest | A2600 | |
| 2091 | Secret Agent Barbie: Royal Jewels Mission | GBA | |
| 3530 | Secret Collect. | A2600 | |
| 231 | Secret of Evermore | SNES | |
| 819 | Secret of Mana | SNES | |
| 3269 | Secret Ties | NES | |
| 3968 | Section Z | NES | |
| 1415 | Sega-Galaga | SG1000 | |
| 4196 | Segapede | Genesis | |
| 3643 | SegaSonic the Hedgehog | Arcade | |
| 3666 | Senkyu | Arcade | |
| 3032 | Serious Sam Advance | GBA | |
| 1227 | Serpent | GB | |
| 2473 | Sesame Street A-B-C | NES | |
| 1719 | Sesame Street Countdown | NES | |
| 2860 | Severed | 3DS | |
| 2082 | Sewer Sam | INTV | |
| 3575 | Shackled | Arcade | |
| 2099 | Shadow Blasters | Genesis |