| Id | Name | Systems | Actions |
|---|---|---|---|
| 1496 | SpongeBob's Atlantis SquarePantis | GBA | |
| 3064 | SpongeBob's Truth or Square | DS | |
| 2475 | Spot: The Video Game | NES | |
| 3557 | Sprilo | NES | |
| 4010 | Spy Defense | C64 | |
| 2037 | Spy Hunter | NES | |
| 3499 | Spy Kids 3-D: Game Over | GBA | |
| 1856 | Spy Muppets: License to Croak | GBA | |
| 1009 | Spy vs. Spy | NES | |
| 1053 | Spyman | Windows | |
| 640 | Spyro 2: Ripto's Rage! | PSX | |
| 3024 | Spyro 2: Season of Flame | GBA | |
| 3074 | Spyro Orange: The Cortex Conspiracy | GBA | |
| 801 | Spyro the Dragon | PSX | |
| 2348 | Spyro: A Hero's Tail | GC | |
| 1485 | Spyro: Attack of the Rhynocs | GBA | |
| 1888 | Spyro: Enter The Dragonfly | GC | |
| 4006 | Spyro: Season of Ice | GBA | |
| 1055 | Spyro: Year of the Dragon | PSX | |
| 741 | Squirrel King | Genesis | |
| 2476 | Stack-Up | NES | |
| 2226 | Stadium Events | NES | |
| 4100 | Stallar | NES | |
| 2789 | Star Anise Chronicles: Oh No Wheres Twig?? | PICO8 | |
| 2167 | Star Control | Genesis |