| Id | Name | Systems | Actions |
|---|---|---|---|
| 3544 | Sixty Seconds to Live | Flash | |
| 2667 | Six Cats Under | Linux | |
| 3516 | Sin and Punishment | N64 | |
| 2675 | Simple 2960 Tomodachi Series Vol. 3: The Itsudemo Puzzle - Massugu Soroeru Straws | GBA | |
| 3760 | Simple 1500 Series Vol.56: The Sniper | PSX | |
| 2224 | Simple 1500 Series Vol.30: The Basket ~1 on 1 Plus~ | PSX | |
| 3891 | Simple 1500 Series Vol. 63: The Gun Shooting 2 | PSX | |
| 4206 | Simon | GBA | |
| 1095 | SimCity | SNES | |
| 2768 | SimAnt: The Electronic Ant Colony | SNES | |
| 853 | Silver Surfer | NES | |
| 1169 | Silkworm | NES | |
| 1998 | Silhouette Mirage | Saturn | |
| 357 | Silent Scope | GBA | |
| 4211 | Silent Hill 1 | PSX | |
| 2970 | Silent Bomber | PSX | |
| 1607 | Silent Assault | NES | |
| 1255 | Side Pocket | Genesis | |
| 2516 | Side Pocket | GB | |
| 2787 | Side Pocket | NES | |
| 1642 | Sid Meier's Railroad Tycoon | DOS | |
| 2474 | Sid Meier's Pirates! | NES | |
| 650 | Sid Meier's Civilization | SNES | |
| 2114 | Shrek: Fairy Tale Freakdown | GBC | |
| 3762 | Shrek the Third | GBA |