| Id | Name | Systems | Actions |
|---|---|---|---|
| 3308 | Sonic & Sega All-Stars Racing | Wii | Versions |
| 4083 | Sonic & Sega All-Stars Racing | DS | Versions |
| 3238 | Son Son | NES | Versions |
| 1116 | Somari | NES | Versions |
| 13 | Solstice: The Quest for the Staff of Demnos | NES | Versions |
| 5 | Solomon's Key | NES | Versions |
| 2325 | Solomon's Club | GB | Versions |
| 2991 | Solomon | GBC | Versions |
| 439 | Solitaire | NES | Versions |
| 3869 | Soldiers of Fortune | Genesis | Versions |
| 3809 | Solatorobo: Red the Hunter | DS | Versions |
| 227 | Solar Jetman: Hunt for the Golden Warpship | NES | Versions |
| 1542 | Sokoban DS | DS | Versions |
| 2271 | Socks the Cat Rocks the Hill | SNES | Versions |
| 3866 | Socket | Genesis | Versions |
| 4027 | SnowBall | PICO8 | Versions |
| 2636 | Snow White in Happily Ever After | SNES | Versions |
| 1256 | Snow Bros.: Nick & Tom | Genesis | Versions |
| 3999 | Snow Bros.: Nick & Tom | Arcade | Versions |
| 4000 | Snow Bros. 2: With New Elves | Arcade | Versions |
| 44 | Snow Bros. | NES | Versions |
| 1346 | Snoopy's Silly Sports Spectacular | NES | Versions |
| 2518 | Snoopy's Magic Show | GB | Versions |
| 2020 | Snoopy and Peanuts | DOS | Versions |
| 2128 | Snoopy | C64 | Versions |