| Id | Name | Systems | Actions |
|---|---|---|---|
| 2423 | Sharp Shot | INTV | Versions |
| 1292 | Shaq Fu | SNES, Genesis | Versions |
| 3446 | Shantae: Risky's Revenge | DSi | Versions |
| 1586 | Shantae | GBC | Versions |
| 939 | Shanghai DS | DS | Versions |
| 3140 | Shaman King: Spirit of Shamans | PSX | Versions |
| 2937 | Shaman King: Master of Spirits 2 | GBA | Versions |
| 2307 | Shaman King: Master of Spirits | GBA | Versions |
| 2655 | Shadowrun | Genesis | Versions |
| 37 | Shadowgate | NES | Versions |
| 34 | Shadow of the Ninja | NES | Versions |
| 573 | Shadow of the Beast II | Genesis | Versions |
| 570 | Shadow of the Beast | Genesis | Versions |
| 1860 | Shadow Man | N64 | Versions |
| 321 | Shadow Dancer: The Secret of Shinobi | Genesis | Versions |
| 2595 | Shadow Dancer | Arcade | Versions |
| 2099 | Shadow Blasters | Genesis | Versions |
| 3575 | Shackled | Arcade | Versions |
| 2082 | Sewer Sam | INTV | Versions |
| 2860 | Severed | 3DS | Versions |
| 1719 | Sesame Street Countdown | NES | Versions |
| 2473 | Sesame Street A-B-C | NES | Versions |
| 1227 | Serpent | GB | Versions |
| 3032 | Serious Sam Advance | GBA | Versions |
| 3666 | Senkyu | Arcade | Versions |