| Id | Name | Systems | Actions |
|---|---|---|---|
| 306 | Shinobi III: Return of the Ninja Master | Genesis | Versions |
| 2063 | Shinobi Legions | Saturn | Versions |
| 720 | Shockman | PCE | Versions |
| 4223 | Shoot for the Moon | GBA | Versions |
| 1886 | Short Order | NES | Versions |
| 2314 | Shounen Ashibe: Goma-chan no Yuuenchi Daibouken | SNES | Versions |
| 4129 | Shove It! ...The Warehouse Game | Genesis | Versions |
| 2075 | Shovel Knight | Linux | Versions |
| 3673 | Show do Milhão | Genesis | Versions |
| 3537 | Show do Milhão Volume 2 | Genesis | Versions |
| 3706 | Shrek 2 | GBA | Versions |
| 3755 | Shrek 2: Beg for Mercy | GBA | Versions |
| 3762 | Shrek the Third | GBA | Versions |
| 2114 | Shrek: Fairy Tale Freakdown | GBC | Versions |
| 650 | Sid Meier's Civilization | SNES | Versions |
| 2474 | Sid Meier's Pirates! | NES | Versions |
| 1642 | Sid Meier's Railroad Tycoon | DOS | Versions |
| 1255 | Side Pocket | Genesis | Versions |
| 2516 | Side Pocket | GB | Versions |
| 2787 | Side Pocket | NES | Versions |
| 1607 | Silent Assault | NES | Versions |
| 2970 | Silent Bomber | PSX | Versions |
| 4211 | Silent Hill 1 | PSX | Versions |
| 357 | Silent Scope | GBA | Versions |
| 1998 | Silhouette Mirage | Saturn | Versions |