| Id | Name | Systems | Actions |
|---|---|---|---|
| 2825 | Sniper Assassin 3 | Flash | Versions |
| 3648 | Sniper: Year One | Flash | Versions |
| 3959 | SNK vs. Capcom: Card Fighters Clash | NGP | Versions |
| 2805 | SNK vs. Capcom: SVC Chaos | Arcade | Versions |
| 3761 | Sno-Cat | C64 | Versions |
| 624 | Snood | GBA | Versions |
| 2128 | Snoopy | C64 | Versions |
| 2020 | Snoopy and Peanuts | DOS | Versions |
| 2518 | Snoopy's Magic Show | GB | Versions |
| 1346 | Snoopy's Silly Sports Spectacular | NES | Versions |
| 44 | Snow Bros. | NES | Versions |
| 4000 | Snow Bros. 2: With New Elves | Arcade | Versions |
| 1256 | Snow Bros.: Nick & Tom | Genesis | Versions |
| 3999 | Snow Bros.: Nick & Tom | Arcade | Versions |
| 2636 | Snow White in Happily Ever After | SNES | Versions |
| 4027 | SnowBall | PICO8 | Versions |
| 3866 | Socket | Genesis | Versions |
| 2271 | Socks the Cat Rocks the Hill | SNES | Versions |
| 1542 | Sokoban DS | DS | Versions |
| 227 | Solar Jetman: Hunt for the Golden Warpship | NES | Versions |
| 3809 | Solatorobo: Red the Hunter | DS | Versions |
| 3869 | Soldiers of Fortune | Genesis | Versions |
| 439 | Solitaire | NES | Versions |
| 2991 | Solomon | GBC | Versions |
| 2325 | Solomon's Club | GB | Versions |