In the third X-Men game on the Game Boy Color (after X-Men: Mutant Academy and Mutant Wars), Lady Deathstrike and her fellow mutants have begun building a weapon that can melt the adamantium skeleton that protects Wolverine. The most famous of the X-Men must now fight through 16 levels to stop her from finishing this weapon.

Besides his main attack, hack-and-slashing with his trademark claws, Wolverine can fly into a rage when the attack button is rapidly pressed. While he is hard to control in this state, his attack range increases, enabling him to get through tougher sections of the game without taking as much damage.

In this run, Noxxa utilizes some physics tricks and precise movement to finish the game in around 11 and a half minutes.