Aliens meet the Illuminati is basically the plot of The Conduit, a First Person Shooter exclusive to the Wii. The game was made in response to the relative lack of more "hardcore" titles for the console at the time. In this title, one plays as Michael Ford fighting against the Trust, a mysterious organization trying to control America, and the Drudge, a race of alien invaders working with the Trust. The player is able to use a variety of weapon types to fight off attackers and makes use of an artifact called the All Seeing Eye to solve puzzles.
In this TAS, NEVERDOORS uses absurd aim, out of bounds, and other glitches to finish the game in under 46 minutes, and in 40:08 ingame time.
Note: There are also lossless encodes and encodes at additional resolutions available in the discussion thread.