Spider-Man 2 was a launch title for the Nintendo DS in North America. Developed by Vicarious Visions and published by Activision, this 2.5D side scroller loosely follows the plot points from the Sam Raimi films, as it sometimes deviates from the movie plot to fill in missions with other Spider-Man villains such as Mysterio and Vulture.

EZGames69 improves the previous movie by 54.61 seconds, thanks to better optimisation and a recently found glitch. Please read the author's comments for more details.