Okay, if and only if this will be a good game to TAS, it will take extreme luck manipulation because it is very difficult and it will take serious movement.
You can get by with Invisible Potions if you pick those up on the way to the first boss, but upgrading Fester's gun to LV 8 takes serious luck manipulation. I was barely able to defeat the first boss with a LV 6 gun and I definitely had to use the Inv. Potions because I was short on health.
http://dehacked.2y.net/microstorage.php/info/1205822508/Fester%27s%20Quest%20%28U%29%20%5B%21%5D.fcm
Don't forget, some of these ROM's are shared on the Web as incomplete, dumped, or both. Sometimes entering a building will cause the game to instantly reset without reason. Make sure you have the ROM name and the checksum listed below or my WIP won't work right.
Fester's Quest (U) [!]
F4F27B27E4F7964B5A6E151B4E4323DA