This game doesn't emulate real well. The sound/music is really bad in all the versions of MAME I've tested, and it has some graphical issues in some cases. The gameplay still remains pretty accurate from my experience, but the other issues are really distracting for me. :P
This is definitely an amazing game, though! A TAS of this should probably just be single player with Ryno because he is undeniably the fastest. A 4P TAS would be really interesting, but significantly slower due to the insane amount of lag and enemies.
This is true, but you can tell MURPHAGATOR!'s route videos on youtube were done on emulator, because you'll see him load a state at the start of some of them, meaning there is an emulator that does this game's sound okay somewhere.