Okay, this is probably about as Off Topic as it's ever going to get on this forum, but i have a bio question. I've been out of school for 6 years now, so i have no way to go back and look anything up.
I understand the 00-A0-B0-AB Relationships in blood types, but i have questions about RH +/-
Simply put, is this another double contribution type? where everyone has either --/-+/++ ... Whereby if you have a + in your mix you are positive, but are capable of passing a - if you also have it? or is it a one type relationship whereas you are either + or -, and a + person is guarantee'd + children no matter what thier mate is. (the latter actually doesn't make sense since we've been reproducing for so many thousands of years, you'd think there would be no -'s left around)
Or is it even deeper, whereas you actually pass on (A-O+) and then math it out from there.
Any help is appreciated. Thanks
Joined: 5/17/2004
Posts: 106
Location: Göteborg, Sweden
Almost all our genetic information is doubled - for males, all of it - so it's reasonable to assume that this includes Rh positivity.
Now, I don't remember my biology lessons well enough to know if you pass one of your two genetic sets to your offspring or if it's a random chance on which half for each of your 23 chromosome pairs. If the former, you'll have one positivity 'setting' linked to the same set as one of your blood types and you'll therefore pass on, say, either A+ or B-.
If the latter, things grow a wee bit more complicated. If the genetic information for blood type and Rh positivity are contained in the same chromosone, it's effectively the same as before. If not, you'll pass on a random combination of the two blood types you carry and the two RH settings you carry. With the previous genes, that's A-, A+, B- or B+.
Err . . . but I'm really not adding much, am I? :) Hopefully, someone who knows more genetics than me reads the forum and can clarify.
The only thing I know about blood type has to do with its influence on diet, hormonal levels, and personality development. And that has nothing to do with +/-.
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Rhesus
Another characteristic of blood is Rhesus factor or Rh factor. Someone either has or does not have the Rh factor on the surface of their red blood cells. This is indicated as + or -. This is often combined with the ABO type. Type O+ blood is most common, though in some areas type A prevails, and there are other areas in which as many as 80 percent of the people are type B.
Matching the Rhesus factor in the ABO system is very important, as mismatching (i.e. an Rh positive donor to an Rh negative recipient) will cause hemolysis.
A second born Rh positive child of an Rh negative mother will also have hematological problems including hemolysis.
Rh factor is named after the Rhesus Monkey where the factor was first identified.
Rhesus inheritance
Rh is inherited the same way, except that it has two alleles and Rh is dominant. Rh Disease occurs when an Rh negative mother who has already had an Rh positive child bears another Rh positive child. The antibodies in the mother's blood react to the infant's blood. This reaction doesn't always occur and is less likely to occur if the child carries either the A or B antigen and the mother does not. In the past, Rh incompatibility could result in stillbirth or death of the mother. Rh incompatibility was until recently the most common cause of long term disability in the United States. At first, this was treated by transfusing the blood of infants who survived. At present, this affliction can be treated with certain anti-Rh(+) antisera, the most common of which is Rhogam.
Joined: 4/25/2004
Posts: 615
Location: The Netherlands
lets see
anyone with
O can receive blood from A B and AB
A can receive from A and AB
B can receive from B and AB
AB can only receive from AB
plus the +- stuff jyzero pasted
thats all i know about bloodtypes (dont even know my own :p)
Almost all our genetic information is doubled - for males, all of it - so it's reasonable to assume that this includes Rh positivity.
The count of chromosomes in humans is 46. Females have two of every one including 2 Xs, males have 2 of the first 22 and then one X and one Y. None of the chromosomes should be identical unless your parents are closely related by blood.
The way genes are passed on is randomized with every generation, so you don't pass on just those of your father or mother, but a mix of both. The Rh factor isn't linked to the ABO genes, so it can be different from the inherited blood type.
Boco wrote:
The only thing I know about blood type has to do with its influence on diet, hormonal levels, and personality development. And that has nothing to do with +/-.
It is currently thought that the antigens arose from environmental factors related to those, but it isn't proven yet. The only thing known is the geographic spreading of the blood types, from which they made those theories.
qFox wrote:
anyone with
O can receive blood from A B and AB
A can receive from A and AB
B can receive from B and AB
AB can only receive from AB
Swap all your "receive from"s with "give to"s.
Type A means you have the A antigens on your red blood cells and hence don't have antibodies for it, meaning you can accept blood from anybody who either has just A antigens or has no antigens, namely A or O.
B works the same way, O indicates you have no antigens on your RBCs.
O can only accept from O but can donate to all (The Universal Donator), A can only accept from A or O and only donate to A or AB, B can only accept from B or O and only give to B or AB, and AB can accept from anybody but only donate to other AB (The Universal Acceptor).
The Rh factor works just like the other antigens in that if you're + you have the antigen on your RBCs and can accept either + or - but only give to other +. Its gene isn't linked to the ABO antigens so their inheritances aren't linked.
