| Id | Name | Systems | Actions |
|---|---|---|---|
| 3687 | South Park | GBC | |
| 2306 | Space Battle | INTV | |
| 3750 | Space Dock | C64 | |
| 3650 | Space Gallery | C64 | |
| 1287 | Space Harrier | 32X | |
| 1378 | Space Invaders | A2600 | |
| 2944 | Space Invaders | GBA | |
| 3017 | Space Invaders Extreme | DS | |
| 663 | Space Invaders Extreme 2 | DS | |
| 2858 | Space Invaders Virtual Collection | Vboy | |
| 3428 | Space Invaders: The Original Game | SNES, SGB | |
| 3502 | Space is Key | Flash | |
| 4171 | Space is Key Hell | Flash | |
| 3834 | Space Megaforce | SNES | |
| 2189 | Space Monsters Meet the Hardy | ZXS | |
| 1975 | Space Quest II: Chapter II - Vohaul's Revenge | DOS | |
| 814 | Space Quest IV: Roger Wilco and the Time Rippers | DOS | |
| 1976 | Space Quest: Chapter I - The Sarien Encounter | DOS | |
| 2227 | Space Shuttle Project | NES | |
| 1755 | Space Station Silicon Valley | N64 | |
| 3940 | Space Worms | C64 | |
| 4051 | Spacegulls | NES | |
| 770 | Spanky's Quest | SNES | |
| 159 | Sparkster | SNES | |
| 482 | Sparkster | Genesis |