| Id | Name | Systems | Actions |
|---|---|---|---|
| 2285 | Spike | VEC | |
| 4172 | Spin-Out! | O2 | |
| 1251 | Spindizzy Worlds | SNES | |
| 749 | Spinmaster | Arcade | |
| 1200 | Spiritual Warfare | NES | |
| 3207 | Spirou | SNES | |
| 2179 | Spirou: The Robot Invasion | GBC | |
| 1713 | Splatterhouse | PCE | |
| 2840 | Splatterhouse | Arcade | |
| 378 | Splatterhouse 2 | Genesis | |
| 3867 | Splatterhouse 3 | Genesis | |
| 331 | Splatterhouse: Wanpaku Graffiti | NES | |
| 1190 | SpongeBob SquarePants: Battle for Bikini Bottom | GC | |
| 3030 | SpongeBob SquarePants: Battle for Bikini Bottom | GBA | |
| 3745 | SpongeBob SquarePants: Creature from the Krusty Krab | GBA | |
| 758 | SpongeBob SquarePants: Legend of the Lost Spatula | GBC | |
| 3026 | SpongeBob SquarePants: Revenge of the Flying Dutchman | GBA | |
| 901 | SpongeBob SquarePants: SuperSponge | PSX | |
| 1999 | SpongeBob SquarePants: SuperSponge | GBA | |
| 1496 | SpongeBob's Atlantis SquarePantis | GBA | |
| 3571 | SpongeBob's Atlantis SquarePantis | DS | |
| 3064 | SpongeBob's Truth or Square | DS | |
| 2475 | Spot: The Video Game | NES | |
| 3557 | Sprilo | NES | |
| 4010 | Spy Defense | C64 |