| Id | Name | Systems | Actions |
|---|---|---|---|
| 894 | Superfast Mario Bros. | NES | |
| 3577 | Superfast Mario Bros. 2 | NES | |
| 4128 | Superfast Mario Bros. 3 | NES | |
| 1286 | Superman | Genesis | |
| 1375 | Superman | A2600 | |
| 1556 | Superman | N64 | |
| 2844 | Superman | GB | |
| 2798 | Superman: The Man of Steel | C64 | |
| 3785 | SuperSprite | C64 | |
| 3709 | SuperTux | Linux, Windows | |
| 3363 | SuperTux (duplicate) | Windows | |
| 722 | Survival Kids | GBC | |
| 2024 | Survival Kids 2: Dasshutsu! Futago Shima! | GBC | |
| 3703 | Susano-o Densetsu | PCE | |
| 3434 | Sushi the Cat | GBA, DS | |
| 3223 | Sutte Hakkun | SNES | |
| 1757 | Suzuki Bakuhatsu | PSX | |
| 4124 | SWAT: Special Weapons and Tactics | NES | |
| 1437 | Sweet Home | NES | |
| 176 | Sword Master | NES | |
| 2892 | Sword of Mana | GBA | |
| 2269 | Sword of Vermilion | Genesis | |
| 2735 | SwordQuest: EarthWorld | A2600 | |
| 3270 | Swords and Serpents | NES | |
| 2576 | Syd of Valis | Genesis |