| Id | Name | Systems | Actions |
|---|---|---|---|
| 27 | DuckTales 2 | NES | |
| 3501 | DuckTales 2 | GB | |
| 1592 | Duke Nukem 3D | Genesis | |
| 397 | Duke Nukem 64 | N64 | |
| 3807 | Duke Nukem Advance | GBA | |
| 2036 | Duke Nukem II | DOS | |
| 649 | Duke Nukem: Episode 1 - Shrapnel City | DOS | |
| 1794 | Duke Nukem: Episode 2 - Mission: Moonbase | DOS | |
| 2021 | Duke Nukem: Episode 3 - Trapped in the Future! | DOS | |
| 3321 | Duke Nukem: Time to Kill | PSX | |
| 3978 | Dune | SegaCD | |
| 858 | Dune II: The Building of a Dynasty | DOS | |
| 1864 | Dune: The Battle for Arrakis | Genesis | |
| 695 | Dungeon Explorer | PCE | |
| 475 | Dungeon Magic: Sword of the Elements | NES | |
| 2957 | Dungeons & Dragons: Eye of the Beholder | GBA | |
| 672 | Dungeons & Dragons: Warriors of the Eternal Sun | Genesis | |
| 3881 | Dunk | C64 | |
| 3832 | Dynamite Duke | Genesis | |
| 380 | Dynamite Headdy | Genesis | |
| 125 | Déjà Vu | NES | |
| 295 | Déjà Vu I & II: The Casebooks of Ace Harding | GBC | |
| 982 | E-SWAT | SMS | |
| 1372 | E.T.: The Extra-Terrestrial | A2600 | |
| 565 | E.V.O.: Search for Eden | SNES |