| Id | Name | Systems | Actions |
|---|---|---|---|
| 150 | Eggerland | FDS | |
| 3282 | Egg Mania: Eggstreme Madness | GC | |
| 3099 | Egg Mania - Tsukande! Mawashite! Dossun Puzzle | GBA | |
| 1718 | Eek! The Cat | SNES | |
| 1821 | Ed, Edd n Eddy: The Mis-Edventures | GC | |
| 3076 | Ed, Edd n Eddy: The Mis-Edventures | GBA | |
| 3102 | eCrew Development Program | DS | |
| 466 | Ecco: The Tides of Time | Genesis | |
| 228 | Ecco the Dolphin | Genesis | |
| 2203 | Earthworm Jim 3D | N64 | |
| 2316 | Earthworm Jim 2 (Shin-Shin) | NES | |
| 1724 | Earthworm Jim 2 | Genesis | |
| 232 | Earthworm Jim | Genesis, SegaCD | |
| 527 | EarthBound Beginnings | NES | |
| 296 | EarthBound | SNES | |
| 330 | Earnest Evans | Genesis | |
| 565 | E.V.O.: Search for Eden | SNES | |
| 1372 | E.T.: The Extra-Terrestrial | A2600 | |
| 982 | E-SWAT | SMS | |
| 295 | Déjà Vu I & II: The Casebooks of Ace Harding | GBC | |
| 125 | Déjà Vu | NES | |
| 380 | Dynamite Headdy | Genesis | |
| 3832 | Dynamite Duke | Genesis | |
| 3881 | Dunk | C64 | |
| 672 | Dungeons & Dragons: Warriors of the Eternal Sun | Genesis |