| Id | Name | Systems | Actions |
|---|---|---|---|
| 2608 | Elite Beat Agents | DS | Versions |
| 920 | Elmo's Letter Adventure | N64 | Versions |
| 4178 | Enchanted: Once Upon Andalasia | GBA | Versions |
| 2187 | Enduro Racer | SMS | Versions |
| 2922 | Enter the Matrix | GC | Versions |
| 687 | Epic Pinball | DOS | Versions |
| 3214 | Equinox | SNES | Versions |
| 1491 | Eryi's Action | Windows | Versions |
| 3013 | Escape from the Mindmaster | A2600 | Versions |
| 3636 | Escape Game | Flash | Versions |
| 3335 | Escape Goat | Linux | Versions |
| 2191 | Esper Dream | FDS | Versions |
| 2564 | ESPN Baseball Tonight | Genesis | Versions |
| 442 | ESWAT: City Under Siege | Genesis | Versions |
| 3283 | Eternal Darkness: Sanity's Requiem | GC | Versions |
| 3558 | Etrian Odyssey | DS | Versions |
| 733 | Evel Knievel | GBC | Versions |
| 990 | Eversion | Windows | Versions |
| 635 | Ex-Mutants | Genesis | Versions |
| 68 | Excitebike | NES | Versions |
| 2875 | Excitebike 64 | N64 | Versions |
| 3315 | Exciting Rally | NES | Versions |
| 3833 | Exile | Genesis | Versions |
| 548 | Extra Mario Bros. | NES | Versions |
| 3253 | F-1 Race | NES | Versions |