The Sinister Six have rejoined in hopes of ruling the world (as usual), but Spider-Man has a lot of errands to do, so he decides to beat all of them in record time.
The mechanics of this game make it difficult to make a fast TAS. If Spider-Man stays in the air too long after a jump, he'll drop straight down, and his web-slinging is easily stopped by enemy projectiles. Despite these obstacles, mmbossman manages to improve the previous movie by over 35 seconds thanks to improved speed management and more efficient boss fights.
Watch this run being played back on a real console.