Mega Man Xtreme 2, like its predecessor game Mega Man Xtreme, pretty much copies content and bosses from the main line of Mega Man X games. However, Xtreme 2 gets ideas and designs from a much wider range of games, ranging all the way from Mega Man X to Mega Man X5. For instance, there is a Parts system allowing upgrades to your characters. However, there is also an original story (though it's still as silly as many Mega Man storylines), along with some new stage designs and bosses.

In this game, both X and Zero are playable. Zero is mostly used at the beginning and ending of the game, while X is used mostly in the middle of the game. Both characters get damage-boosting parts from the shop to defeat bosses incredibly quickly. For more information, see the detailed submission comments.

This run starts from a save file in order to unlock "Extreme Mode", which allows visiting all of the game's stages and battles in one run. Runs that start from SRAM are not normally allowed; see the Movie Rules for more on this.

Viewers who have photosensitivity problems may want to avoid watching as there's a high amount of flashing visuals during boss fights that can become uncomfortable to watch.