It is several years after the death of Dr. Von Frankenbone, and things around the castle are starting to fall apart. The electricity bill hasn't been paid in some time, and now the Frankenstein-like character Franky needs to find the cash to pay it off. The locals have trapped Franky inside the late doctor's private manor, and he must escape and piece together the golden tablet depicting his beautiful girlfriend Bitsy in order to pay the bills.

Dr. Franken II is a side-scrolling platformer that places you in control of Franky as he searches far and wide for the pieces of the golden tablet, including exotic locales like Egypt and the bottom of the ocean. Like the first Dr. Franken, there are many trap doors, monsters, and other obstacles. Keys are needed to unlock new areas of the game, and they can be found in the far reaches of the level.

The author, Flip, runs and jumps through the levels with precision, completing the tablet and saving Franky's home, improving the previous movie by ~43 seconds.