One year after the defeat of Amakusa from within the first Samurai Shodown, a new threat soon emerges in the form of Mizuki Rashojin: a vengeful spirit who possess a local shrine priestess named Bizuki and seeks to bring forth chaos and destruction to the world in the name of the dark god Ambrosia's will. Those who had fought before in the past during Amakusa's reign of terror now find themselves, along with a few new faces, battling against Mizuki and her loyal forces in order to determine the fate of the entire world itself.

Samurai Shodown II is a 1994 fighting game released as a second entry in SNK's Samurai Shodown series.