Just like its predecessor, Spider-Man 2 is based on the 2004 movie of the same name, featuring Tobey Maguire as Peter Parker and Alfred Molina as Otto Octavius. It was the first open-world superhero game, and had brand new physics-based web swinging.
The game expands the plot of the film, where the player web-slings and crawls through a virtual New York. Hero points advance the plot and can be collected by doing good deeds and beating up bad guys.
Natetheman223 plays through all of the pizza delivery missions in the game, which is a fan favorite side quest.
You can watch this run with written commentary by the author here.