3-tsu no E no Heya Kara no Dasshutsu 6 (3つの絵の部屋からの脱出6, Escape From the Room With the Three Portraits 6) is an escape room-style Flash game by Yomino Kagura and the fifth sequel to 3-tsu no E no Heya Kara no Dasshutsu. In this iteration of the setting, the portraits now have to be interacted with as part of the overall puzzle. It still has clues on them like with previous iterations, but they now have to be clicked on to proceed and find the key needed to escape the room.

Rxser once again knows exactly what to do in this run and finds the key to the exit as fast as possible.