| Id | Name | Systems | Actions |
|---|---|---|---|
| 3440 | Zaxxon | INTV | |
| 208 | Zelda II: The Adventure of Link | FDS, NES | |
| 478 | Zen: Intergalactic Ninja | NES | |
| 2218 | Zen: Intergalactic Ninja | GB | |
| 279 | Zero the Kamikaze Squirrel | SNES, Genesis | |
| 1593 | Zero Tolerance | Genesis | |
| 1117 | Zero Wing | Genesis | |
| 2413 | Zero4 Champ II | PCECD | |
| 950 | Zillion | SMS | |
| 3975 | Zillion II: The Tri Formation | SMS | |
| 3953 | Zing Zing Zip | Arcade | |
| 3268 | Zippy Race | NES | |
| 3473 | Zippy the Porcupine | A2600 | |
| 2555 | Zoboomafoo: Playtime in Zobooland | GBC | |
| 243 | Zoda's Revenge: StarTropics II | NES | |
| 3249 | Zombie Nation | NES | |
| 203 | Zombies Ate My Neighbors | SNES | |
| 3045 | Zoo Keeper | DS | |
| 1738 | Zook Hero Z | GBC | |
| 1889 | Zook Man ZX4 | GBA | |
| 2009 | Zool: Ninja of the "Nth" Dimension | Genesis | |
| 2185 | Zool: Ninja of the "Nth" Dimension | SMS | |
| 2828 | Zoom 909 | SG1000 | |
| 3792 | Zoom! | Genesis | |
| 2403 | Zork I: The Great Underground Empire | AppleII |