| Id | Name | Systems | Actions |
|---|---|---|---|
| 2269 | Sword of Vermilion | Genesis | Versions |
| 2892 | Sword of Mana | GBA | Versions |
| 176 | Sword Master | NES | Versions |
| 1437 | Sweet Home | NES | Versions |
| 4124 | SWAT: Special Weapons and Tactics | NES | Versions |
| 1757 | Suzuki Bakuhatsu | PSX | Versions |
| 3223 | Sutte Hakkun | SNES | Versions |
| 3434 | Sushi the Cat | GBA, DS | Versions |
| 3703 | Susano-o Densetsu | PCE | Versions |
| 2024 | Survival Kids 2: Dasshutsu! Futago Shima! | GBC | Versions |
| 722 | Survival Kids | GBC | Versions |
| 3363 | SuperTux (duplicate) | Windows | Versions |
| 3709 | SuperTux | Linux, Windows | Versions |
| 3785 | SuperSprite | C64 | Versions |
| 2798 | Superman: The Man of Steel | C64 | Versions |
| 1286 | Superman | Genesis | Versions |
| 1375 | Superman | A2600 | Versions |
| 1556 | Superman | N64 | Versions |
| 2844 | Superman | GB | Versions |
| 4128 | Superfast Mario Bros. 3 | NES | Versions |
| 3577 | Superfast Mario Bros. 2 | NES | Versions |
| 894 | Superfast Mario Bros. | NES | Versions |
| 2343 | Super Win the Game | Linux | Versions |
| 3202 | Super Widget | SNES | Versions |
| 1316 | Super Valis IV | SNES | Versions |