| Id | Name | Systems | Actions |
|---|---|---|---|
| 1975 | Space Quest II: Chapter II - Vohaul's Revenge | DOS | Versions |
| 814 | Space Quest IV: Roger Wilco and the Time Rippers | DOS | Versions |
| 1976 | Space Quest: Chapter I - The Sarien Encounter | DOS | Versions |
| 2227 | Space Shuttle Project | NES | Versions |
| 1755 | Space Station Silicon Valley | N64 | Versions |
| 3940 | Space Worms | C64 | Versions |
| 4051 | Spacegulls | NES | Versions |
| 770 | Spanky's Quest | SNES | Versions |
| 159 | Sparkster | SNES | Versions |
| 482 | Sparkster | Genesis | Versions |
| 1484 | Spartan X 2 | NES | Versions |
| 1237 | Spawn | SNES | Versions |
| 2986 | Spawn | GBC | Versions |
| 4163 | Spectral Tower | PSX | Versions |
| 4168 | Speedway! | O2 | Versions |
| 2901 | Speedy Gonzales | GB | Versions |
| 564 | Speedy Gonzales: Aztec Adventure | GBC | Versions |
| 842 | Speedy Gonzales: Los Gatos Bandidos | SNES | Versions |
| 4213 | Spellbound Dizzy | C64 | Versions |
| 289 | Spelunker | NES | Versions |
| 1651 | Spelunker II: Yūsha e no Chōsen | NES | Versions |
| 1571 | Spelunky | Windows | Versions |
| 1377 | Spider-Man | A2600 | Versions |
| 1735 | Spider-Man | N64 | Versions |
| 2301 | Spider-Man | GC | Versions |