Chameleon Twist 2 (カメレオンツイスト2) takes place after the events in Chameleon Twist. Davy and his friends (Jack, Fred and Linda) are playing in the forest, still carrying the backpack from his last adventure, when suddenly the rabbit from before falls down and knocks one of the chameleons into the sky.

Contrary to the Chameleon Twist run, all 6 levels need to be played through in order to reach the end; Sky Land, Carnival Land, Ice Land, Great Edo Land, Toy Land and Pyramid Land.