Based on the 1988 Michael Keaton movie, Beetlejuice follows the rough storyline of the movie. It is an action platformer where the lead character can run, jump, and stomp his way through the house while collecting "scare points" to help in his ultimate goal. In some portions, the game changes from being a side-scrolling platformer to a more typical action game with a top-down view. The house is equipped with all manner of traps including incinerating lasers, and even the torches hurt.

ktwo improves on their previous movie by 2.72 seconds through better strategies and optimizations, often involving getting hurt.