Reproducing MUGG's bug. Starting an Adventure with Ctrl+N lets you enter the basement, but be unable to click anything in the room. The Game, Location, etc. menus in the window titlebar work, as does anything that looks like a Windows button ("Play a friend", "Call it a night", "OK"), so you can warp around with those menus and their keyboard shortcuts. But anywhere you warp to, you can't click on beds, doors, people, map icons, anything. Pool games work fine, but as soon as you get to your aunt's room in Las Vegas, you're softlocked. You can't skip the plane flight cutscene either, since it requires a click.
This movie starts the game, clicks the bed and door a few times to demonstrate that they don't work, then uses menus and keyboard shortcuts to advance time by warping and "calling it a day" until it's time for the Pool Hall'sl 9-Ball tournament.
MUGG has the solution for this: save your game with Ctrl+S, choose any one-character filename for speed (extension is added automatically), then F4 (not Ctrl+L, the bug will still be active then) and load your save by typing its single character.