Keio Flying Squadron 2 is a multi-genre game for the Sega Saturn and the sequel to Keio Flying Squadron. Unlike the previous game, it was released only in Japan and Europe. And also different in terms of gameplay, while the first game was strictly a side-scrolling shoot 'em up, this game also includes platforming levels that appear to be inspired by other games such as Donkey Kong Country and Yoshi's Island 2.

Taking place sometime after the first game, Keio Flying Squadron 2 starts out with super powered bunnygirl Rami having a nice dinner with her grandparents when a thief named Yamatai Himiko barges in and steals the family snow globe. After a brief chase, Dr. Pon Eho, the final villain from the previous game, intervenes and steals the snow globe while also dropping a nuke on Rami's home. Luckily, he also drops a map with locations of all the other snow globes. Rami goes off on an adventure to find those snow globes and sell them for some cash.

SpectralPlatypus in this run fights off lots of strange and mystifying creatures and bosses to achieve yet another comedic ending for Rami as fast as possible with the help of some platforming tricks and a little pain and gain for Rami.