Just like its predecessor, Spider-Man 2 is based on the 2004 movie of the same name, featuring Tobey Maguire as Peter Parker and Alfred Molina as Otto Octavius. It was the first open-world superhero game, and had brand new physics-based web swinging.

The game expands the plot of the film, where the player web-slings and crawls through a virtual New York. Hero points advance the plot and can be collected by doing good deeds and beating up bad guys.

Natetheman223 web-slings through the game as fast as only a spider can, collecting just enough hero points to complete the story and dispatching villains at record speeds. Natetheman223 improves on his previous run by 2:37.28 minutes via numerous improvements to the entire run, including but not limited to frame-perfect Spidey Reflexes, placing civilians on theater lamps, and taking no damage.

The author has provided voice commentary for this movie.